Tuberculosis (TB) is a common and often deadly chronic bacterial infectious disease caused by a bacterium called mycobacterium, kills four people every minute some-where in the world and accounts about two million deaths per year. Isatin is a versatile lead molecule for designing of potential anti-microbial and anti-TB agents. Using this pharmacophore, it was envisaged that its combined effect with an active moiety may result in increased anti-microbial and anti-TB activity. Quinolones were found to be active against wide range of bacteria and also for some fungi. Synthesis of amide linkage containing some novel compounds using these two versatile moieties (isatin and quinolones) have been done and checked for their anti-microbial and anti-TB activity. With the base of dual concept, amide bond going to metabolize first and two moieties get separated where both having individual activity like anti-TB and other activities. 5-subsituted-1H-indole-2,3-dione-3-thiosemicarbazides were prepared by using 5-subsituted-1H-indole-2,3-dione and thiosemicarbazide and formed Schiff base with quinolones as ofloxacin and levofloxacin synthesized five novel derivatives containing amide linkage and one novel derivative synthesized using 1Hindole- 2,3-dione-3-thiosemicarbazide was treated with ester of ciprofloxacin. All the synthesized derivatives were confirmed by spectral analysis. With the study it was found that in compare to levofloxacin and ciprofloxacin as standard, novel compounds shows good to moderate activity against E. coli, S. aureus and C. albicans and also shows moderate anti-TB activity against H37Rv strain of M. tuberculosis.
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